Microbiology Engineering Research and Development Center

Data:26-12-2019  |  【 A  A  A 】  |  【Print】 【Close

     The center has 90 research technicians, and 11 of them with senior professional title.
     Research fields: The research activities of Microbiology Engineering Research and Development Center are focused on six fields, including 1. the foundation of the database about spoilage microorganisms in industrial products and on human skin; 2. the spoilage mechanism of biodeteriorative microorganisms; 3. the mechanism of how the industrial bactericide worked; 4. the fundamental research of the mechanism of the microbial resistant; 5.the study on the new testing technology and safety evaluation of anti-mildew and antibacterial property; 6. the basic research on microbial ecology and skin health; 7.Through synthetic biology methods to carry out the applied basic research about bacteriocin, antibacterial peptides, antioxidant peptides, biosurfactant, nucleoside drugs and other bioactive substances; and 8. at the same time we carry out the research and development about new anti-mildew and antibacterial materials, biodegradable materials, biomedical polymer materials and biomedical composite materials. Especially, the biodeteriorative microbiology is one of the four domestic preponderant disciplines in our institute, and also one of the five domestic research and development areas.
     Research objectives: To build a world-class research platform for the spoilage mechanism and control of biodeteriorative microorganisms, a research base for new antibacterial materials, biodegradable materials and biomedical materials, and to build the largest database of mold and rot microorganisms and body surface microorganisms in China. The center has established "Guangdong Engineering Research Center for Antimicrobial Materials and Antimicrobial Testing", "Guangdong Key Research Base for Environment-friendly Anti-mildew and Antibacterial New materials" and "Guangdong Materials (products) Anti-mildew and antibacterial testing and safety evaluation center".
     Achievements: Presided over 60 research projects of national, ministerial and provincial level; successively gained 30 scientific and technological achievements, including 12 science and technology awards such as National Science & Technology Progress Award and other city-lever or above awards, published more than 280 papers (64 included in SCI), published 3 related monographs, applied 78 invention patent (40 authorized), chaired or participated in developing more than 40 national and industry standards .

1. Research on the feed antifungal agent FC??won Second Class Prize of Science and Technology Progress Award of Guangdong Province in 1988.
2. Study on Breeding of Glutamic acid Mutant and Fermentation Process?won Second Class Prize of Science and Technology Progress Award of Guangdong Province in 1989.
3. Production of inosine using high-yield technology?won Second Class Prize of Science and Technology Progress Award of Guangdong Province in 1996.
4. Production of inosine using high-yield technology?won Third Class Prize of the National Scientific and Technological Progress Award in 1997.
5. Quality and comprehensive development of Meizhou Shaddock(CITRUS GRANDIS)?won First Class Prize of Science and Technology Progress Award of Guangdong Province in 2002.
6. FZ/T 73023?2006 Antibacterial knitwear won Second Class Prize of Science and Technology Award of China Textile Industry Association in 2010.
7. Development of Application Technology of Microbial Control Engineering in Papermaking?won Second Class Prize of Science and Technology Award of Guangdong Province in 2012.
8. Production of ? - polyglutamic acid and its preparation?won Outstanding award of Guangdong invention patent award in 2013.
9. A fungicide for wood plastic composite and its preparation?won Gold medal of Guangdong Patent Award in 2016.

National Standard:
1. GB/T 24128-2018 Plastics桝ssessment of the effectiveness of fungistatic compounds in plastics formulations
2. GB/T 37247-2018 Test method for evaluating antifungal activity of photocatalytic materials and products
3. GB/T 35469-2017 Test method of anti-mold activity of building wood-plastic composites
4. GB/T 31402?015 Plastics桵easurement of antibacterial activity on plastics surfaces
5. GB/T 30792?014 Test method for resistance of water-borne coatings in the container to attack by microorganisms
6. GB/T 1741-2007 Test method for determining the resistance of painsfilm to mold
7. GB/T 24127-2009 Testing method for determining algal resistance of plastics
8. GB/T 21353-2008 Test method for determining the resistance of paint film to algae
9. GB/T 24346-2009 Textiles - Evaluation for anti-mould activity
10. GB/T 24253-2009 Textiles - Evaluation for anti-mites activity
11. GB/T 33610.2-2017 Textiles桪etermination of deodorant propertyPart 2:Detector tube method
12. HG/T 4301-2012 Test method for determination of ruber to fungi
13. FZ/T 62012-2009 Anti-mite bedding
14. JC/T 2496-2018 Antimildew and water resistant putty
15. JC/T 2497-2018 Antimildew and water resistant gypsum plaster mortar
16.GB/T 30706-2014 Measurment method and evaluating of the antibacterial characteristics of photocatalysis materials under visible light irridation
17. GB/T 23763-2009 Photo-catalytic antimicrobial materials and products - Assessment for antimicrobial activity and efficacy
18. JC/T 897?014 Aseptic function of antibacterial ceramic
19. QB/T 2738-2012 Test methods for evaluatingdaily chemical products in antibacterial and bacteriastatic efficacy
20. QB/T 4371?012 Evelation for antibacterial activity of furniture
21. FZ/T 60030-2009 Anti-mould activity assessment of home textile
22. GB/T 2423.16?009 Environmental testing for electrial and electronic products-Part 2:Test methods-Test J and guidance :Mould growth

1.Antibacterial activity of silver-carried sodium zirconium phosphate prepared by ion-exchange reaction. Journal of the Ceramic Society of Japan, 2008,116(6): 767-770.
2.Dissociation of outer membrane for Escherichia coli cell caused by cerium nitrate. Journal of rare earths, 2010, 28 (2): 312~315.
3.Preparation and Characterization of Antibacterial Zn2+-Exchanged Montmorillonites. Journal of Wuhan University of Technology-Mater.2010, 25(5): 725~729.
4.Antibacterial activity and mechanism of silver nanoparticles on Escherichia coli, Applied Microbiology and Biotechnology, 2010( 85):1115?122.
5.Structure and synergetic antibacterial effect of zinc and cerium carried sodium zirconium phosphates ,Journal of rare earths, 2011, 29 (4): 308~312..
6.Structure and antibacterial activity of copper-carried zirconium phosphates. Advanced Materials Research. 2011,150~151:852~856. (EI??)
7.Antibacterial effect of silver nanoparticles on Staphylococcus aureus. Biometals,2011,24:135?41.
8.Effect of Ce3+ on membrane permeability of Escherichia coli cell, JOURNAL OF RARE EARTHS, 2012, 30(9): 947-951.(SCI\EI???)
9.Synthesis, characterization and antimicrobial activity of zinc and cerium co-doped a-zirconium phosphate,JOURNAL OF RARE EARTHS, 2012, 30(8): 820-825.
10.Humic analog AQDS and AQS as an electron mediator can enhance chromate reduction by Bacillus sp.strain 3C3. Applied Microbiology and Biotechnology. 2012, 93: 2661-2668.
11.Synergistic antibacterial zinc ions and cerium ions loaded alpha-zirconium phosphate, Materials Letters, 2012, 67(1): 199-201.
12.Antifungal effects of citronella oil against Aspergillus niger ATCC 16404. Applied Microbiology and Biotechnology,2013,97:7483?492
13.Preparation and characterization of poly (?-glutamic acid)-graft-chitosan/chitosan porous scaffolds for tissue engineering,9th world biomaterials congress,2012
14.Effect of different conditions on the average degree of polymerization of bacterial cellulose produced by Gluconacetobacter intermedius BC-41,Cellulose Chemistry and Technology,2013,47(7-8):503-508.
15.Poly-l-lysine-modified reduced graphene oxide stabilizes the copper nanoparticles with higher water-solubility and long-term additively antibacterial activity,Colloids and Surfaces B: Biointerfaces,2013,107 :107?114
16.Involvement of outer membrane proteins and peroxide-sensor genes in Burkholderia cepacia resistance to isothiazolone. World Journal of Microbiology and Biotechnology. 2014, 30:1251?260? 2013,DOI 10.1007/s11274-013-1538-3
17.Effects of nutritional and environmental conditions on planktonic growth and biofilm formation of Citrobacter werkmanii BF-6. Journal of Microbiology and Biotechnology. 2013,23(12):1673-1682. (SCI,IF=1.399)
18.Preparation and Antibacterial Property of Waterborne Polyurethane/Zn朅l Layered Double Hydroxides/ZnO Nanocomposites. Journal of Nanoscience and Nanotechnology. 2013, 13: 409?16
19.Mold resistance and water absorption of Wood/HDPE and Bamboo/HDPE composite. Journal of applied Science. 2014,14(8):776-783.(EI)
20.Antifungal effect and mechanism of garlic oil on Penicillium funiculosum. Appl Microbiol Biotechnol. 2014, 98(19):8337-8346.
21.Design and in vitro evaluation of novel ?-PGA/hydroxyapatite nanocomposites for bone tissue engineering. Journal of Material Science, 2014, 49(22): 7742-7749.
22.Efficacy of metal ions and isothiazolones in inhibiting Enterobacter cloacae BF-17 biofilm formation. Can. J. Microbiol. 2014, 60:5-14.
23.Preparation and Characterization of a Novel ?-PGA/?Tricalcium Phosphate Composite for Tissue. Engineering Advanced Materials Research, 201,900,: 306-311. (EI)
24.Preparation and antibacterial properties of activated carbon spheres - quaternary phosphonium salt composite. RSC Advances. 2014, 4:50708?0712.
25.Antimicrobial activity of silver nanoparticles in situ growth on TEMPO-mediated oxidized bacterial cellulose. Cellulose. 2014, 21:4557?567
26.Antifungal effect and mechanism of garlic oil on Penicillium funiculosum. Applied Microbiology and Biotechnology. 2014, 98:8337-8346.
27.Antibacterial activity and kinetics of litsea cubeba oil on Escherichia coli. PLOS ONE. 2014,9(11):e110983 1-6.
28.Insights into Pseudomonas aeruginosa ATCC 9027 resistance to isothiazolones through proteomics. Microbial Drug Resistance. 2015,21(2):140-148. 2014, ahead of print. doi:10.1089/mdr.2014.0113. (SCI, IF=2.524)
29.Transforming sugarcane bagasse into bioplastics via homogeneous modification with phthalic anhydride in ionic liquid. ACS Sustainable Chemistry & Engineering 2015, 10.1021/acssuschemeng.5b00685. (IF: 4.642,) ACS Sustainable Chem. Eng., 2015, 3 (10): 2510?515
30.The three bacterial lines of defense against antimicrobial agents. International Journal of Molecular Sciences 2015, 16(9):21711-21733.
31.Effects of volatile chemical components of wood species on mould growth susceptibility and termite attack resistance of wood plastic composites. International biodeterioration & biodegradation, 2015, 100: 106-115.
32.Algal decay resistance of conventional and novel wood-based composites,Bioresources,2015,10(4):6321-6331.
33.Waterborne polyurethane/NiAl-LDH/ZnO composites with high antibacterial activity. Polymers for Advanced Technologies. 2015, 26(5):495?01.
34.Proteome responses of Citrobacter werkmanii BF-6 planktonic cells and biofilms to calcium chloride. Journal of Proteomics. 2016,133 :134?43. http://dx.doi.org/10.1016/j.jprot.2015.12.019. (IF: 3.888) Journal of Proteomics 133 (2016) 134?43
35.Effects of Fungicides on Mold Resistance and Mechanical Properties of Wood and Bamboo Flour/High-Density Polyethylene Composites. Bioresources,2016,11(2):4069-4085.
36.Antifungal activity, kinetics and molecular mechanism of action of garlic oil against Candida albicans. Scientific Reports | 6:22805 | DOI: 10.1038/srep22805.(2016)
37.Poly (?-glutamic acid)/beta-TCP nanocomposites via in situ copolymerization: Preparation and characterization. Journal of Biomaterials Applications,2016, 31(1): 102?11.((PMID:26945810)(2016)
38.Comparison of transcriptomes of wild-type and isothiazoloneresistant Pseudomonas aeruginosa by using RNA-seq. Molecular Biology Reports. 2016,DOI 10.1007/s11033-016-3978-y 2016,43(6):527?40.
39.p杙conjugations improve the long-term antibacterial properties of graphene oxide/quaternary ammonium salt nanocomposites. Chemical Engineering Journal,2016 304: 873?81.
40.Thermal stability of sugarcane bagasse derivatives bearing carboxyl groups synthesized in ionic liquid. Bioresources,2016,11(3):6254-6266.
41.Homogeneous Modification of Sugarcane Bagasse by Graft Copolymerization in Ionic Liquid for Oil Absorption Application. International Journal of Polymer Science. 2016, DOI: 10.1155/2016/6584597.
42.Controlled release and long-term antibacterial activity of reduced graphene oxide/quaternary ammonium salt nanocomposites prepared by non-covalent modification. Colloids and Surfaces B: Biointerfaces,2017, 149: 322?29.
43.Improved production of poly-?-glutamic acid with low molecular weight under high ferric ion concentration stress in Bacillus licheniformis ATCC 9945a. Process Biochemistry, 2017, 56:30-36. DOI: 10.1016/j.procbio.2017.02.017.
44.Purification and molecular weight distribution of a key exopolysaccharide component of Bacillus megaterium TF10. Journal of Environmental Sciences. 2018, 63:9-15. http://dx.doi.org/10.1016/j.jes.2016.12.006
45.Homogeneous Transesterification of Sugar Cane Bagasse toward Sustainable Plastics. ACS Sustainable Chemistry & Engineering. 2017, 5 (1):360?66 (IF: 5.267) 2016, DOI: 10.1021/acssuschemeng.6b01735.
46.Effects of biocide treatments on durability of wood and bamboo/highdensity polyethylene composites against algal and fungal decay. J. APPL. POLYM. SCI. 2017, DOI: 10.1002/APP.45148 JOURNAL OF APPLIED POLYMER SCIENCE,2017,DOI: 10.1002/app.45148
47.The dynamics and mechanism of the antimicrobial activity of tea tree oil against bacteria and fungi. Applied Microbiology and Biotechnology. 2016, 100, 8865-8875. (IF: 3.376) DOI 10.1007/s00253-016-7692-4
48.Facile pyrolysis preparation of rosin-derived biochar for supporting silver nanoparticles with antibacterial activity. Composites Science and Technology,2017,145:89-95
49.Monitoring the crystalline structure of sugar cane bagasse in aqueous ionic liquids. ACS Sustainable Chem. Eng. 2017, 5, 7278-7283
50.Conformations and molecular interactions of poly-?-glutamic acid as a soluble microbial product in aqueous solutions . Scientific Reports,2017,7: 12787 | DOI:10.1038/s41598-017-13152-2
51.Combined delivery of BMP-2 and IGF-1 from nano-?-poly(glutamic acid)/?TCP-based calcium phosphate cementand its effect on bone regeneration. Journal of Biomaterials Applications. 2017, 32(5): 547-560
52.Diallyl disulfide from garlic oil inhibits Pseudomonas aeruginosa virulence factors by inactivating key quorum sensing genes. Applied Microbiology and Biotechnology,2018,https://doi.org/10.1007/s00253-018-9175-2
53.Hydrogen bonding impact on chitosan plasticization. Carbohydrate Polymers, 2018,200 :115?21.
54.Antibacterial Nanorods Made of Carbon Quantum Dots-ZnO Under Visible Light Irradiation. Journal of Nanoscience and Nanotechnology. 2018,18:1-9.
55.A comparative analysis of antibacterial activity, dynamics, and effects of silver ions and silver nanoparticles against four bacterial strains. International Biodeterioration & Biodegradation. 2017, 123: 304-310.
56.Role of Ttca of CitrobacterWerkmanii in Bacterial Growth, Biocides Resistance, Biofilm Formation and Swimming Motility. International Journal of Molecular Sciences,2018, 19, 2644; doi:10.3390/ijms19092644
57.Versicolorin A is a potential indicator of aflatoxin contamination in the granary-stored corn. Food Additives & Contaminants: Part A. 2018,35(5): 972-984.
58.Relationship between primary structure or spatial conformation and functional activity of antioxidant peptides from Pinctada fucata. Food Chemistry. 2018, 264, 108-117.
59.Enhancement of photoelectrochemical activity of Fe2O3 nanowires decorated with carbon quantum dots. International journal of hydrogen energy. xxx ( 2018) 1-9.
60.Diallyl disulphide from garlic oil inhibits Pseudomonas aeruginosa virulence factors by inhibiting the transcription of key quorum sensing. Applied Microbiology and Biotechnology. 2018,102:7555-7564.
61.Antibacterial Nanorods Made of Carbon Quantum Dots-ZnO Under Visible Light Irradiation. Journal of Nanoscience and Nanotechnology. 2018,18:1-9.
62.Enhanced synergistic effects of xylitol and isothiazolones on the inhibition of initial biofilm formation by Pseudomonas aeruginosa ATCC 9027 and Staphylococcus aureus ATCC 6538, respectively. Journal of Oral Science, 2018, in press.
63.Self-assembly of cationic amphiphilic cellulose-g-poly (p-dioxanone) copolymers. Carbohydrate Polymers ,2019,204 :214?22.
64.Carbon quantum dot-decorated TiO2 for fast and sustainable antibacterial properties under visible-light,Journal of Alloys and Compounds,2019,777 : 234-243.
65.Silver loaded delaminated hectorite for antibacterial. Micro Nano Letters. 2018/04/02 00:17:31
66.Diallyl disulfide from garlic oil inhibits Psuedomonas aeruginosa quorum sensing systems and corresponding virulence factors.. Frontiers in Microbiology. 2018, DOI: 10.3389/fmicb.2018.03222.
67.Degradable polymeric package from whole cell wall biomass. Materials Today Sustainability 3-4 (2019) 100008. https://doi.org/10.1016/j.mtsust.2019.100008
68.Pyrolysis preparation of poly-?-glutamic acid derived amorphous carbon nitride for supporting Ag and ?-Fe2O3 nanocomposites with catalytic and antibacterial activity Materials Science & Engineering C ,2019,101:138?47.
69.Waterborne polyurethane composites with antibacterial activity by incorporating p-BzOH intercalated MgAl-LDH. Composites Communications , 2019,13 :112?18.
70.Enhanced synergistic effects of xylitol and isothiazolones for inhibition of initial biofilm formation by Pseudomonas aeruginosa ATCC 9027 and Staphylococcus ureus ATCC 6538.Journal of Oral Science, 2019, 61(2):255-263.
71.Montmorillonite-Modified Reduced Graphene Oxide Stabilizes Copper Nanoparticles and Enhances Bacterial Adsorption and Antibacterial Activity. ACS Appl. Bio Mater. 2019, 2, 1842-1849.
72.Effects of wood fiber properties on mold resistance of wood polypropylene composites. International Biodeterioration & Biodegradation .2019,140 :152?59.
73.Silver-loaded delaminated hectorite nanoparticles for antibacterial materials. Micro & Nano Letters, 2019, 14(5):531?33. doi: 10.1049/mnl.2018.5017.
74.Lingling Wang, Yamin Liu, Xiulin Shu, Shunying Lu, Xiaobao Xie, Qingshan Shi. Complexation and conformation of lead ion with poly-?-glutamic acid in soluble state. PLOS ONE, 2019,https://doi.org/10.1371/journal.pone.0218742