Globally, the prevalence of overweight/obesity is increasing rapidly. Obesity and its complications not only seriously affect the quality of life of patients, but also bring a heavy economic burden to society and families. Low carbohydrate diets (LCD) is a dietary intervention mode for weight loss treatment. However, in different studies, the weight loss effects of LCD intervention are quite different. There is not enough evidence to explain this difference. This is a qualitative phenomenon, which is also a difficult point in the field of medical weight management.
The study selected 51 male or female (18-65-year-old) subjects who met the diagnostic criteria for overweight/obesity (no antibiotics or drugs were used in the first 3 months of the clinical trial). The subjects were randomized into groups and were divided into different groups. The energy-restricted normal diet (ND) group and the non-calorie-restricted low-carbohydrate diet group (LCD). The diet intervention time was 12 weeks. The results of the study show that in overweight/obese people, short-term LCD intervention without calorie restriction has a significant weight loss effect without significant adverse effects. There are individual differences in short-term LCD weight loss. The relative abundance of Bacteroidaceae Bacteroides at baseline before LCD intervention is positively correlated with the short-term LCD intervention weight loss effect. Finally, the study constructed a high-precision ANN prediction model based on the relative abundance of the intestinal flora at the baseline. Through the ANN prediction model, it was found that the baseline relative abundance of the intestinal flora can be used as a predictor of the individualized weight loss effect before LCD intervention. It has important guiding significance for clinical medicine weight management.